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研究実績

1. 高血圧・動脈硬化・循環器疾患関連(論文数:37)

Miki S et al. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469.
Kunimura K et al. S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway. Cell Commun Signal. 2021; 19: 17.
Ushijima M et al. S-1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway Exp Ther Med. 2020 Sep; 20(3):2815-2821.
Matsutomo T Potential benefits of garlic and other dietary supplements for the management of hypertension (Review) Exp Ther Med. 2020; 19(2):1479-1484.
Matsutomo T et al. Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. J Pharm Biomed Anal. 2019 Feb 12; 168:148-154.
Tsuneyoshi T et al. S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019 Jan 8; 84: 22-29.
Ushijima M et al. Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats. J Pharm Pharmacol. 2018 Apr; 70(4): 559-565.
Hiramatsu K et al. Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expressions via Nrf2-ARE pathway in human endothelial cells. Nutrition Research, 2016;36(2):143-9.
Matsutomo T et al. Metabolomic study on the antihypertensive effect of S-1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 1;1046:147-155.
Morihara N, Hino A. Aged garlic extract suppresses platelet aggregation by changing the functional property of platelets. J Nat Med. 2017; 71:249-256.
牛島光保. 熟成ニンニク抽出液の末梢循環改善作用. FOOD Style 21. 2017;21(12):75-77.
Takashima M et al. Aged garlic extract exerts endothelium-dependent vasorelaxant effect on rat aorta by increasing nitric oxide production. Phytomedicine. 2017 Jan 15;24:56-61.
Morihara N et al. Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice. J Nutr. 2016 Feb;146(2):460S-463S.
Tsuneyoshi T et al. Dehydrodiconiferyl alcohol suppresses monocyte adhesion to endothelial cells by attenuation of JNK signaling pathway. Biochem Biophys Res Commun. 2015 Sep 25; 465(3): 408-13.
Yamakawa T et al. Aged garlic extract and one of the constituent, (+)-(2S,3R)-Dehydrodiconiferyl alcohol, inhibits alkaline phosphatase activity induced by inflammation factors in human vascular smooth muscle cells. Food and Nutrition Science. 2014; 5(2): 177-184.
Weiss N et al. Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation. J Ethnopharmacol. 2013; 145(1): 162-7.
Morihara N et al. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. J Ethnopharmacol. 2011; 134(3): 711-6.
Morihara N et al. Aged garlic extract inhibits CD36 expression in human macrophages via modulation of the PPARgamma pathway. Phytother Res. 2010; 24(4): 602-8.
Abahji TN et al. Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction. Arch Med Res. 2007; 38(4): 411-6.
Weiss N et al. Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro-and microcirculation. J Nutr. 2006 Mar;136(3 Suppl):750S-754S.
Ide N et al. Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages. J Nutr. 2006 Mar;136(3 Suppl):755S-758S.
Morihara N et al. Aged garlic extract maintains cardiovascular homeostasis in mice and rats. J Nutr. 2006 Mar;136(3 Suppl):777S-781S.
Morihara N et al. Aged garlic extract inhibits peroxynitrite-induced hemolysis. Redox Rep. 2005; 10(3): 159-65.
Budoff MJ et al. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004; 39(5): 985-91.
Morihara N et al. Aged garlic extract enhances production of nitric oxide. Life Sci. 2002; 71(5): 509-17.
Ide N, Lau BH. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J Nutr. 2001; 131(3s): 1020S-6S.
Ho SE et al. S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process. Phytomedicine. 2001; 8(1): 39-46.
Matsuura H. Saponins in garlic as modifiers of the risk of cardiovascular disease. J Nutr. 2001; 131(3s): 1000S-5S.
Moriguchi T et al. The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes. J Nutr. 2001; 131(3s): 1016S-9S.
Ide N, Lau BH. Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine. 1999; 6(2): 125-31.
Ide N et al. Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract. J Nutr. Biochem. 1999; 10(6): 372-6.
Ide N, Lau BH. S-allylcysteine attenuates oxidative stress in endothelial cells. Drug Dev Ind Pharm. 1999; 25(5): 619-24.
住吉博道. にんにくの抗酸化作用、成人病予防食品の開発. 1999; 91-98. シーエムシー出版.
Ide N et al. Aged garlic extract and its constituents inhibit Cu(2+)-induced oxidative modification of low density lipoprotein. Planta Med. 1997; 63(3): 263-4.
Ide N, Lau BH. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. J Pharm Pharmacol. 1997; 49(9): 908-11.
山崎毅. にんにく製剤およびにんにく由来イオウ化合物の抗酸化能. 日薬理誌. 1997; 110: 138-141.
Yamasaki T et al. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. Phytother Res. 1994; 8: 408-12.

2. 糖尿病・内分泌疾患関連論文一覧(論文数:10)

Miki S et al. Mechanisms underlying the attenuation of chronic inflammatory diseases by aged garlic extract: Involvement of the activation of AMP-activated protein kinase (Review) Exp Ther Med. 2020; 19(2):1462-1467.
Ohtani M et al. Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing the intercellular adhesion molecule-1 expression and IL-6 secretion. Biomedical Reports. 2020 Mar; 12(3):99-108.
Maeda T et al. Aged garlic extract ameliorates fatty liver and insulin resistance and improves the gut microbiota profile in a mouse model of insulin resistance. Exp Ther Med. 2019 Jul; 18(1):857-866.
Miki S et al. Aged garlic extract suppresses the increase of plasma glycated albumin level and enhances the AMP-activated protein kinase in adipose tissue in TSOD mice. Mol Nutr Food Res. 2017 May;61(5): 1600797.
Adachi Y et al. Bis(allixinato)oxovanadium(IV) complex is a potent antidiabetic agent: Studies on structure-activity relationship for a series of hydroxypyrone-vanadium complexes. J Med Chem. 2006 Jun 1;49(11):3251-6.
Adachi Y et al. Improvement of diabetes, obesity and hypertension in type 2 diabetic KKAy mice by bis(allixinato)oxovanadium(IV) complex. Biochem Biophys Res Commun. 2006 Jul 7;345(3):945-50.
Adachi Y et al. A highly potent insulin-mimetic zinc(II) complex a Zn(S2O2) coordination mode : Bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1,4-dihydropyridine-4-thionato)zinc(II). Chemistry Letter. 2005; 34(5): 656-657.
Adachi Y et al. A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes. J Biol Inorg Chem. 2004; 9(7): 885-93.
春日繁男ほか. マウスのストレス性高血糖に対するニンニク抽出液(AGE)の作用. 日本薬理学雑誌. 1999;114(3):191-7.
永井勝次, 中川静紀. 糖尿病におよぼすニンニク,ニンジン抽出液の影響. 薬理と治療. 1974; 2(9): 1473-89.

4. 認知機能・アルツハイマー病・精神・神経疾患(論文数:20)

Kohda K et al. Enhancing effect of aged garlic extract on induction of morphological differentiation with neurite outgrowth in NGF-Treated PC12 Cells. Pharmacol. Pharm. 2012; 3: 37-43.
武田秀勝ほか. 学生の試験ストレスに対する熟成ニンニク抽出液(AGE)の効果. 北方産業衛生. 2011;48:15-20.
守口徹. 認知症治療に有効と考えられる生薬 <ニンニクの部分>. 認知症治療薬開発の最前線.2006; CMC出版社.
木本理可ほか. 熟成ニンニク抽出液の摂取が大学生の臨床実習における尿中8-OHdG排泄量,NK細胞活性およびPOMS得点に与える影響. 北海道教育大学紀要. 2005; 56(1): 47-53.
Ito Y et al. Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid beta-protein-induced cell death in nerve growth factor-differentiated PC12 cells. Neurosci Res. 2003; 46(1):119-25.
Moriguchi T, Saito H. Aged garlic extract as a neurotrophic and anti-aging agent. Piante Medicinali. 2002; 1(3):114-28.
Nishiyama N et al. Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice. J Nutr. 2001; 131(3s): 1093S-5S.
Sumi S et al. Isolation and characterization of the genes up-regulated in isolated neurons by aged garlic extract (AGE). J Nutr. 2001; 131(3s): 1096S-9S.
住吉博道. ニンニクが脳機能に及ぼす作用. Food Style21. 1999; 3: 36-40.
Moriguchi T et al. Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity. Life Sci. 1997;61(14): 1413-20.
Moriguchi T et al. Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model. Clin Exp Pharmacol Physiol. 1997; 24(3-4): 235-42.
Nishiyama N et al. Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse. Exp Gerontol. 1997;32(1-2): 149-60.
Ushijima M et al. Effect of garlic and garlic preparations on physiological and psychological stress in mice. Phytother Res. 1997; 11(3): 226-30.
Moriguchi T et al. Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons. Neurochem Res. 1997; 22(12): 1449-52.
Moriguchi T et al. Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse. Biol Pharm Bull. 1996;19(2): 305-7.
Nishiyama N et al. Effects of aged garlic extract on senescence accelerated mouse and cultured brain neurons. Int Acad Biomed Drug Res. 1996;11:253-8.
Moriguchi T et al. Tropic effects of aged garlic extract (AGE) and its fractions on primary cultured hippocampal neurons from fetal rat brain. Phytother Res. 1996; 10: 468-72.
Moriguchi T et al. Effects of aged garlic extract (AGE) on impairments of learning and memory performances in senescence accelerated mouse. Int. Conf. on Senescence (1st): The SAM Model of Senescence. 1994;447-50.
Moriguchi T et al. Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract. Biol Pharm Bull. 1994;17(12): 1589-94.
Takasugi N et al. Effect of garlic on mice exposed to various stresses. 応用薬理. 1984; 28(6): 991-1002.

5. 身体的疲労関連(論文数:4)

Morihara N et al. Garlic as an anti-fatigue agent. Mol Nutr Food Res. 2007; 51(11): 1329-34.
Morihara N et al. Aged garlic extract ameliorates physical fatigue. Biol Pharm Bull. 2006; 29(5): 962-6.
木本理可ほか. 熟成ニンニク抽出液が日常定期的運動負荷時および一時的最大運動負荷時の尿中8-OHdG含有量推移に及ぼす影響. 北海道スポーツ医・科学雑誌. 2005;10: 17-26.
春日繁男. ニンニク抽出液が持久性運動負荷による生体に及ぶ影響. 北海道スポーツ医・科学雑誌. 1998; 6: 29-36.

6. 免疫機能関連(論文数:16)

鈴木順一朗 熟成ニンニク抽出液の免疫調整作用 FOOD Style 21. 2021;25(1):53-5.
Suzuki J et al. Regulation of immune response by S-1-propenylcysteine throught autophagy-mediated protein degradation (Review) Exp Ther Med. 2020; 19(2):1570-1573.
Kanamori Y et al. Aged garlic extract and its constituent, S-allyl-L-cysteine, induce the apoptosis of neuroblastoma cancer cells due to mitochondrial membrane depolarization Exp Ther Med. 2020; 19(2):1511-1521.
Agostinelli E et al. The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability. Int J Oncol. 2018 Sep; 53(3):1257-1268.
Suzuki J et al. Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci Rep. 2018 Sep 20; 8(1):14148.
Suzuki J et al. S-1-Propenylcysteine promotes the differentiation of B cells into IgA-producing cells by the induction of Erk1/2-dependent Xbp1 expression in Peyer’s patches. Nutrition. 2016 Jul-Aug;32(7-8):884-9.
Kyo E et al. Immunomodulatory effects of aged garlic extract. J Nutr. 2001; 131(3s): 1075S-9S.
Kasuga S et al. Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. J Nutr. 2001; 131(3s): 1080S-4S.
Kyo E. Garlic as an immunostimulant. Immunomodulatory Agents from Plants. 1999;273-288. Birkhauser Verlag Basel,Switzerland.
Kyo E et al. Prevention of psychological stress-induced immune suppression by aged garlic extract. Phytomedicine. 1999; 6(5): 325-30.
Zhang Y et al. Functional relationship between age-related immunodeficiency and learning deterioration. Eur J Neurosci. 1998; 10(12): 3869-75.
Kyo E et al. Immunomodulation and antitumor activities of Aged Garlic Extract. Phytomedicine. 1998; 5(4): 259-67.
Lau BH et al. Garlic compounds modulate macrophage and T-lymphocyte functions. Mol Biother. 1991; 3(2): 103-7.
HiraoY et al. Activation of immunoresponder cells by the protein fraction from aged garlic extract. Phytother Res. 1987; 1(4): 161-4.
永井勝次. ウイルスの感染防御に及ぼすニンニク抽出液の影響. 日本感染症学会雑誌. 1973; 47(4): 111-15.
永井勝次. ニンニク抽出液のインフルエンザ感染防御に及ぼす影響. 日本感染症学会雑誌. 1973; 47(9): 321-25.

7. 安全性関連(論文数:12)

Amano H et al. Evaluation of the Effects of S-Allyl-L-cysteine, S-Methyl-L-cysteine, trans-S-1-Propenyl-L-cysteine, and Their N-Acetylated and S-Oxidized Metabolites on Human CYP Activities. Biol. Pharm. Bull. 2016;39(10):1701-1707.
Amano H et al. Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs. Xenobiotica. 2016 Nov;46(11):1017-25.
Amano H et al. Pharmacokinetics of S-Allyl-l-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption. J Nutr. 2016 Feb;146(2):456S-459S.
Amano H et al. Metabolism, Excretion, and Pharmacokinetics of S-Allylcysteine in Rats and Dogs. Drug Metabolism and Disposition. 2015; 43(5): 749-755.
Matsutomo T et al. Pharmacokinetics of water soluble organosulfur compounds from garlic. J Clin Biochem Nutr. 2008; 43(supple 1):100-4.
Ichikawa M et al. Pharmacokinetics of cycloalliin, an organosulfur compound found in garlic and onion, in rats. J Agric Food Chem. 2006; 54(26): 9811-9.
Kodera Y et al. Pharmacokinetic study of allixin, a phytoalexin produced by garlic. Chem Pharm Bull (Tokyo). 2002; 50(3): 354-63.
Amagase H. Role of maker compounds of herbs and their bioavailability in quality, efficacy and safety of products. Quality Management of Nutraceuticals, 2001; 803(Chapter 5): 63-75.
吉田進ほか. ニンニクの変異原性試験および細胞毒性試験. J Toxicol Sci. 1984; 9: 77-86
住吉博道ほか. ニンニク抽出液のラットにおける6ヶ月慢性毒性試験. J Toxicol Sci. 1984; 9(1): 61-75.
中川静紀ほか. ニンニク抽出液の急性毒性試験. J Toxicol Sci. 1984;9:57-60.
中川静紀ほか. 生ニンニクおよびニンニク抽出液の経口投与による若年ラットの発育,諸臓器などへの影響. J Toxicol Sci. 1980; 5: 91-112.

8. 熟成ニンニク抽出液の構成成分と分析結果関連(論文数:51)

Abe K et al. Identification and Characterization of Sulfur Heterocyclic Compounds That Contribute to the Acidic Odor of Aged Garlic Extract. J. Agric. Food Chem. 2021, 69, 3, 1020–1026
Abe K et al. Volatile compounds of fresh and processed garlic (Review) Exp Ther Med. 2020; 19(2):1585-1593.
Kodera Y et al. Chemistry of aged garlic: Diversity of constituents in aged garlic extract and their production mechanisms via the combination of chemical and enzymatic reactions (Review) Exp Ther Med. 2020; 19(2):1574-1584.
Kurita M et al. 3-Allyltrisulfanyl-alanine Formation during the Preparation of Aged Garlic Extract J Agric Food Chem. 2020; 68:14577-83.
Nakamoto M et al. Identification and determination of antibacterial constituents in residue discharged from garlic-processing plant Eur Food Res Technol. 2020; 246:1041-1049.
Myoda T et al. Characterization of key aroma compounds in aged garlic extract Food Chem. 2019 Dec 24; 312: 126081.
Hofmann, T et al. Targeted Screening and Quantitative Analyses of Antioxidant Compounds in Aged Garlic Extract. Eur Food Res Technol. 2018 October; 244(10):1803-1814.
Kodera Y et al. Changes of S-allylmercaptocysteine and γ-glutamyl-S-allylmercaptocysteine contents and their putative production mechanisms in garlic extract during the aging process. J Agric Food Chem. 2018 Sep 18; 66, (40): 10506–10512.
Nakamoto M et al. Isolation and Identification of Three γ-Glutamyl Tripeptides and Their Putative Production Mechanism in Aged Garlic Extract. J Agric Food Chem. 2018 Mar 21;66(11):2891-2899.
Kodera Y et al. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract. Molecules. 2017 Mar 31;22(4): 570.
Matsutomo T et al. Development of a fast and sensitive UPLC-MS/MS method for quantitation of dilignols in aged garlic extract. European Food Research and Technology. 2016 Jun; 242(6): 849-854.
Matsutomo T, Kodera Y. Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection. J Nutr. 2016 Feb;146(2):450S-455S.
Wakamatsu J et al. Taste-Active Maillard Reaction Products in Roasted Garlic (Allium sativum). J Agric Food Chem. 2016 Jul 27;64(29):5845-54.
Yoshimoto N et al. Garlic γ-glutamyl transpeptidases that catalyze deglutamylation of biosynthetic intermediate of alliin. Front Plant Sci. 2015 Jan 8; 5: 758.
Kodera Y et al. The Evidence for the Production Mechanism of cis-S-1-Propenylcysteine in Aged Garlic Extract Based on a Model Reaction Approach Using Its Isomers and Deuterated Solvents. Planta Med Lett. 2015; 2(01): e69-e72.
Yoshimoto N et al. Identification of a flavin-containing S-oxygenating monooxygenase involved in alliin biosynthesis in garlic. Plant J. 2015 Sep; 83(6): 941-51.
Matsutomo T et al. In Vitro Activity-Guided Identification of Antioxidants in Aged Garlic Extrac. Journal of Agricultural and Food Chemistry. 2013, 61(12); 3059-3067.
Ichikawa M et al. Changes in organosulfur compounds in garlic cloves during storage. J Agric Food Chem. 2006; 54(13): 4849-54.
Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006 Mar;136(3 Suppl):716S-725S.
Ichikawa M et al. Determination of seven organosulfur compounds in garlic by high-performance liquid chromatography. J Agric Food Chem. 2006; 54(5): 1535-40.
Ichikawa M et al. Tetrahydro-beta-carboline derivatives in aged garlic extract show antioxidant properties. J Nutr. 2006 Mar;136(3 Suppl):726S-731S.
Ichikawa M et al. Antioxidant effcts of tetrahydro-beta-carboline derivatives identified in aged garlic extract. ACS SYMPOSIUM SERIES 871, Nutraceutical Beverages Chemistry, Nutrition, and Health Effects. 2003; 28: 380-404.
Ide N et al. Antioxidants in Processed Garlic: Tetrahydro-β-carboline derivatives in aged garlic extract. ACS SYMPOSIUM SERIES 851, Food Factors in Health Promotion and Disease Prevention. 2003;22:250-263.
Kodera Y et al. Garlic chemistry: Chemical and biological properties of sulfur-containing compounds derived from garlic. ACS Symposium series 851, Food Factors in Health Promotion and Disease Prevention. 2003;30:346-357.
Ichikawa M et al. Identification of six phenylpropanoids from garlic skin as major antioxidants. J Agric Food Chem. 2003; 51(25): 7313-7.
Ryu K et al. Liquid Chromatography-Mass Spectrometry Method for Fructosylarginine , an Antioxidant in the Aged Garlic Extract. ACS SYMPOSIUM SERIES 851, Food Factors in Health Promotion and Disease Prevention, 2003;23: 264-273.
Ryu K, Rosen RT. Unique Chemistry of Aged Garlic Extract. ACS SYMPOSIUM SERIES 859, Oriental Foods and Herbs. 2003; 19:258-270.
Kodera Y et al. Allixin accumulation with long-term storage of garlic. Chem Pharm Bull (Tokyo). 2002; 50(3): 405-7.
Ichikawa M et al. Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract. Biofactors. 2002; 16(3-4): 57-72.
Ide N et al. Antioxidants in processed garlic Ⅱ. Tetrahydro-beta-carboline derivatives indentified in aged garlic extract. Int Cong Ser. 2002;1245:449-50.
Ide N et al. Antioxidants in processed garlic I. Fructosyl arginine indentified in aged garlic extract. Int Cong Ser. 2002; 1245: 447-8.
Kodera Y et al. Physical, chemical, and biological properties of s-allylcysteine, an amino acid derived from garlic. J Agric Food Chem. 2002; 50(3): 622-32.
Ryu K et al. N alpha-(1-deoxy-D-fructos-1-yl)-L-arginine, an antioxidant compound identified in aged garlic extract. J Nutr. 2001; 131(3s): 972S-6S.
Kodera Y et al. Allixin induction and accumulation by light irradiation. Chem Pharm Bull (Tokyo). 2001; 49(12): 1636-7.
Tsuneyoshi T et al. Differentiation of Allium carlaviruses isolated from different parts of the world based on the viral coat protein sequence. Arch Virol. 1998; 143(6): 1093-107.
Matsumura Y et al. Facile Synthesis of Allixin and Its Related Compounds. Tetrahedron Lett. 1998; 39: 2339-40.
Inagaki M et al. Isolatin and structure determination of cerebrosides from garlic, the bulbs of Allium sativum L. Chem Pharm Bull (Tokyo). 1998; 46: 1153-6.
Kyo E et al. Anti-allergic effects of aged garlic extract. Phytomedicine. 1997; 4(4): 335-40.
住吉博道. ニンニク及びその成分の新しい薬理活性. 日薬理誌.1997; 110 suppl 1:93-97.
Matsuura H et al. Changes in contents of gamma-glutamyl peptides and fructan during growth of Allium sativum. Planta Med. 1996; 62(1): 70-1.
Ide N et al. Scavenging effect of aged garlic extract and its constutuent on active oxygen species. Phytother Res. 1996;10: 340-1.
Freeman F, Kodera Y. Garlic chemistry: Stability of S-(2-Propenyl) 2-Propene-1-sulfinothioate(Allicin)in blood, solvents, and simulated physiological fluids. J Agric Food Chem. 1995; 43(9): 2332-8.
Imai J et al. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Med. 1994; 60(5): 417-20.
Nagae S et al. Pharmacokinetics of the garlic compound S-allylcysteine. Planta Med. 1994; 60(3): 214-7.
Horie T et al. Identified diallyl polysulfides from an aged garlic extract which protects the membranes from lipid peroxidation. Planta Med. 1992; 58(5): 468-9.
Yamasaki T et al. Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1. Cancer Lett. 1991; 59(2): 89-94.
Matsuura H et al. A furostanol glycoside from Allium chinese G. Don. Chem Pharm Bull (Tokyo). 1989; 37(5): 1390-1391.
Kodera Y et al. Allixin, a stress compound from garlic. Chem Pharm Bull (Tokyo). 1989; 37(6): 1656-8.
Matsuura H et al. A furostanol glycoside from garlic, bulbs of Allium sativum L. Chem Pharm Bull (Tokyo). 1988; 36(9): 3659-3663.
Morita T et al. Steroidal saponins from elephant garlic, bulbs of Allium ampeloprasum L. Chem Pharm Bull (Tokyo). 1988; 36(9): 3480-6.
高原征一ほか. ニンニクから得られた脂肪酸エステルによるmonoamine oxidaseの阻害. 栄養と食糧.

9. その他(論文数:29)

Nakamoto M et al. Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene and diallyl polysulfides (Review) Exp Ther Med. 2020; 19(2):1550-1553.
Ohtani M et al. The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review) Exp Ther Med. 2020; 19(2):1507-1510.
Tsuneyoshi T BACH1 mediates the antioxidant properties of aged garlic extract (Review) Exp Ther Med. 2020; 19(2):1500-1503.
Hofmann, T et al. Antioxidative Maillard Reaction Products Generated in Processed Aged Garlic Extract. J Agric Food Chem. 2019 Feb 27; 67(8):2190-2200.
Yamato O et al. Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes BMC Vet Res. 2018 Nov 29; 14(1):373.
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