創薬 2025.12

Tahara T et al. Opposite effects of spermidine and GC7 in cell culture are dictated by distinct molecular targets. Biochem J. 2025 Dec 17;482(24):1973-1992.

創薬 2025.05

Ureshino H, Ueshima T, Yamaguchi T, Takashima M, Sanuki Y et al. (R)-WAC-224, a new anticancer quinolone, combined with venetoclax and azacitidine overcomes venetoclax-resistant AML through MCL-1 downregulation. Sci Rep. 2025 May 8;15(1):16018.

9. その他ヘルスケア 2025.04

Kuang C, Nango H, Ohtani M et al. Effects of aged garlic extract on experimental periodontitis in mice. Biomed Rep. 2025 Apr 11;22(6):97.

9. その他ヘルスケア 2025.03

Nakazawa S, Kurata K et al. Allicin induced AMPK signaling attenuated Smad3 pathway mediated lung fibrosis. Sci Rep. 2025 May 30;15(1):19060.

7. 動態・安全性関連S1PCヘルスケア 2025.03

Nakamoto M, Kunimura K, Ohtani M. Pharmacokinetics of sulfur-containing compounds in aged garlic extract: S-Allylcysteine, S-1-propenylcysteine, S-methylcysteine, S-allylmercaptocysteine, and others (Review). Exp Ther Med. 2025 Mar 26;29(5):102.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2025.03

Miki S, Takashima M, Suzuki J. Anti-atherosclerotic effect of aged garlic extract: Its mode of action and therapeutic benefits (Review). Exp Ther Med. 2025 Mar 26;29(5):104.

9. その他ヘルスケア 2025.01

Ohishi K et al. Effects of aged garlic extract (AGE) on aging-related changes in gastrointestinal function and enteric nervous system cells. Exp Ther Med. 2025 Mar 26;29(5):103.

創薬 2025.01

Ohishi K et al. Resolving Resident Colonic Muscularis Macrophage Diversity and Plasticity During Colitis. Inflamm Bowel Dis. 2025 Jan 6;31(1):151-168.

6. 免疫機能関連ヘルスケア 2024.12

Fujii D, Nango H, Ohtani M. Aged garlic extract enhances the production of β-defensin 4 via activation of the Wnt/β-catenin pathway in mouse gingiva. Exp Ther Med. 2024 Dec 30;29(2):41.

6. 免疫機能関連ヘルスケア 2024.11

Takashima M, Kurita M, Terai M, Suzuki J et al. S-allylmercaptocysteine inhibits TLR4-mediated inflammation through enhanced formation of inhibitory MyD88 splice variant in mammary epithelial cells. Sci Rep. 2024 Nov 28;14(1):29627.

創薬 2024.11

Angabo S, Kawasaki H et al. CD47 and thrombospondin 1 contribute to immune evasion by Porphyromonas gingivalis. Proc Natl Acad Sci U S A. 2024 Nov;121(47):e2405534121.

5. 身体的疲労関連S1PCヘルスケア 2024.09

Kunimura K, Nakamoto M, Ushijima M. S-1-Propenylcysteine enhances endurance capacity of mice by stimulating fatty acid metabolism via muscle isoform of carnitine. J Nutr. 2024 Sep;154(9):2707-2716.

創薬 2024.07

Rahman AA, Ohishi K et al. Enteric neural stem cell transplant restores gut motility in mice with Hirschsprung disease. JCI Insight. 2024 Jul 23;9(17):e179755.

創薬 2024.06

Yamamoto K, Kazamori D, Seo K et al. Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target. Nat Commun. 2024 Jun 14;15(1):5085.

バイオ 2024.06

Falco M, Takeuchi T et al. Identification and bioinformatic characterization of a serum miRNA signature for early detection of laryngeal squamous cell carcinoma. J Transl Med. 2024 Jul 10;22(1):647.

創薬 2024.04

Saba E, Kawasaki H et al. Oral bacteria accelerate pancreatic cancer development in mice. Gut. 2024 Apr 5;73(5):770-786.

創薬 2024.03

Pan W, Ohishi K et al. Autologous cell transplantation for treatment of colorectal aganglionosis in mice. Nat Commun. 2024 Mar 20;15(1):2479.

創薬 2024.02

Matsuzaki S et al. REMOVER-PITCh: microhomology-assisted long-range gene replacement with highly multiplexed CRISPR-Cas9. In Vitro Cell Dev Biol Anim. 2024 Aug;60(7):697-707.

創薬 2024.01

Rahman AA, Ohishi K et al. Optogenetic activation of cholinergic enteric neurons reduces inflammation in experimental colitis. Cell Mol Gastroenterol Hepatol. 2024;17(6):907-921.

創薬 2023.12

Guyer RA, Ohishi K et al. Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state. Dis Model Mech. 2023 Dec 1;16(12):dmm049754.

9. その他ヘルスケア 2023.11

Takahashi K, Nango H, Ushijima M, Takashima M, Nakamoto M, Matsutomo T, Jikihara H et al. Therapeutic effect of aged garlic extract on gingivitis in dogs. Front. Vet. Sci. 2023 Nov;10:1277272.

創薬 2023.09

Mino T, Ueshima T, Kashimoto N, Yamaguchi T et al. A novel anticancer quinolone, (R)-WAC-224, has anti-leukemia activities against acute myeloid leukemia. Invest New Drugs. 2023 Oct;41(5):751-760.

6. 免疫機能関連S1PCヘルスケア 2023.04

Nango H, Ohtani M. S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts. PLoS One. 2023 Apr 21;18(4):e0284713.

バイオ 2023.03

Nakamura T, Shirouzu T, Kawai S. Myeloid-Derived Suppressor Cells Suppress Both Serum and Intragraft Donor-Specific Antibody Development in a Mouse Cardiac Transplant Model. Exp Clin Transplant. 2023 Mar;21(3):288-289.

バイオ 2023.03

Uchida T, Shirouzu T, Kawai S et al. A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system. J Viral Hepat. 2023 Mar;30(3):262-272.

7. 動態・安全性関連ヘルスケア 2023.02

Nakamoto M and Kunimura K. Study of the metabolism of S-allylmercaptocysteine to elucidate its metabolites and metabolic pathway in rats. Eur Food Res Technol. 2023;249:1377-1389.

創薬 2022.10

Lemecha M, Takamuku Y et al. Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia. Mol Metab. 2022 Dec;66:101612.

9. その他ヘルスケア 2022.10

Abe K et al. Protective effects of volatile components of aged garlic extract against ultraviolet B-induced apoptosis in human skin fibroblasts. J Food Biochem. 2022 Dec;46(12):e14482.

バイオ 2022.06

Nakamura T, Shirouzu T, Kawai S et al. Intra-Liver Allograft C3d-Binding Donor-Specific Anti-HLA Antibodies Predict Rejection After Liver Transplantation. Transplant Proc. 2022 Mar;54(2):450-453.

バイオ 2022.03

Falco M, Takeuchi T et al. Overview on Molecular Biomarkers for Laryngeal Cancer: Looking for New Answers to an Old Problem. Cancers (Basel). 2022 Mar 28;14(7):1716.

バイオ 2021.12

Nakamura T, Shirouzu T, Kawai S et al. The Abundance of Anti-Galactose-deficient IgA1 Autoantibodies Results in Glomerular Deposition and IgA Nephropathy Recurrence after Renal Transplantation. Transplantation. 2021 Dec 1;105(12):e407-e408.

6. 免疫機能関連S1PCヘルスケア 2021.11

Miki S, Suzuki J, Takashima M et al. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469.

バイオ 2021.10

Nakamura T, Shirouzu T. Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants. J Clin Med. 2021 Nov 19;10(22):5417.

創薬 2021.08

Takashima M et al. Localized and systemic inflammatory mediators in a murine acute mastitis model. J Inflamm Res. 2021 Aug 21;14:4053-4067.

バイオ 2021.08

Shimabukuro S, Kawai S, Shirouzu T et al. Improved detection of donor-specific HLA-class II antibody in kidney transplant recipients by modified immunocomplex capture fluorescence analysis. Transpl Immunol. 2021 Aug;67:101418.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2021.06

Abe K et al. Identification and Characterization of Sulfur Heterocyclic Compounds That Contribute to the Acidic Odor of Aged Garlic Extract. J Agric Food Chem. 2021 Jan 27;69(3):1020-1026.

6. 免疫機能関連ヘルスケア 2021.06

鈴木順一朗. 熟成ニンニク抽出液の免疫調整作用. FOOD Style 21. 2021;25(1):53-55.

1. 高血圧・動脈硬化・循環器疾患関連S1PCヘルスケア 2021.06

Kunimura K, Miki S, Takashima M, Suzuki J. S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway. Cell Commun Signal. 2021 Feb 15;19(1):17.

創薬 2021.06

Kawasaki H, Amano H. Anti-inflammatory role of microRNA-429 in human gingival epithelial cells-inhibition of IL-8 production through direct binding to IKKβ mRNA. Mol Med Rep. 2021 Aug;24(2):581.

バイオ 2021.05

Ricciardiello F, Takeuchi T et al. Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature-A New Goal for Early Diagnosis and Therapy? J Clin Med. 2021 May 8;10(9):2019.

バイオ 2021.02

Yanagawa S, Shirouzu T, Kawai S et al. Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA). PLoS One. 2021 Feb 5;16(2):e0236614.

創薬 2020.10

Okazaki Y et al. Increased glucose metabolism in Arid5b -/- skeletal muscle is associated with the down-regulation of TBC1 domain family member 1 (TBC1D1). Biol Res. 2020 Oct 6;53(1):45.

1. 高血圧・動脈硬化・循環器疾患関連S1PCヘルスケア 2020.09

Ushijima M, Kunimura K, Suzuki J. S-1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway. Exp Ther Med. 2020 Sep;20(3):2815-2821.

創薬 2020.06

Kawasaki H, Takeuchi T et al. Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion. Mol Ther Nucleic Acids. 2020 Jun 5;20:711-724.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2020.06

Abe K et al. Volatile compounds of fresh and processed garlic (Review) Exp Ther Med. 2020 Feb;19(2):1585-1593.

6. 免疫機能関連S1PCヘルスケア 2020.06

Suzuki J, Miki S, Ushijima M, Kodera Y. Regulation of immune response by S-1-propenylcysteine throught autophagy-mediated protein degradation. Exp Ther Med. 2020 Feb;19(2):1570-1573.

6. 免疫機能関連ヘルスケア 2020.06

Miki S, Suzuki J, Kunimura K, Morihara N. Mechanisms underlying the attenuation of chronic inflammatory diseases by aged garlic extract: Involvement of the activation of AMP-activated protein kinase (Review). Exp Ther Med. 2020 Feb;19(2):1462-1467.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2020.06

Matsutomo T. Potential benefits of garlic and other dietary supplements for the management of hypertension (Review). Exp Ther Med. 2020 Feb;19(2):1479-1484.

9. その他ヘルスケア 2020.06

Ohtani M, Nishimura T. The preventive and therapeutic application of garlic and other plant ingredients in the treatment of periodontal diseases (Review). Exp Ther Med. 2020 Feb;19(2):1507-1510.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2020.06

Kodera Y, Kurita M, Nakamoto M, Matsutomo T. Chemistry of aged garlic: Diversity of constituents in aged garlic extract and their production mechanisms via the combination of chemical and enzymatic reactions (Review). Exp Ther Med. 2020 Feb;19(2):1574-1584.

9. その他ヘルスケア 2020.06

Tsuneyoshi T. BACH1 mediates the antioxidant properties of aged garlic extract (Review). Exp Ther Med. 2020 Feb;19(2):1500-1503.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2020.06

Kurita M, Matsutomo T, Kodera Y. 3-Allyltrisulfanyl-alanine Formation during the Preparation of Aged Garlic Extract. J Agric Food Chem. 2020 Dec 9;68(49):14577-14583.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2020.06

Nakamoto M, Ohishi K, Kunimura K, Amano H, Wakamatsu J. Identification and determination of antibacterial constituents in residue discharged from garlic-processing plant. Eur Food Res Technol. 2020 Mar 10;246:1041-1049.

創薬 2020.05

Takeuchi T, Kawasaki H et al. Insight toward the MicroRNA Profiling of Laryngeal Cancers: Biological Role and Clinical Impact. Int J Mol Sci. 2020 May 24;21(10):3693.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2020.03

Abe K et al. Characterization of key aroma compounds in aged garlic extract. Food Chem. 2020 Mar 15;312:126081.

6. 免疫機能関連S1PCヘルスケア 2020.03

Ohtani M, Nishimura T. Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing the intercellular adhesion molecule-1 expression and IL-6 secretion. Biomed Rep. 2020 Mar;12(3):99-108.

9. その他ヘルスケア 2020.02

Nakamoto M, Kunimura K, Suzuki J, Kodera Y. Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene and diallyl polysulfides (Review). Exp Ther Med. 2020 Feb;19(2):1550-1553.

バイオ 2019.09

Nakamura T, Shirouzu T et al. The Role of Major Histocompatibility Complex in Organ Transplantation- Donor Specific Anti-Major Histocompatibility Complex Antibodies Analysis Goes to the Next Stage. Int J Mol Sci. 2019 Sep;20(18):4544.

バイオ 2019.08

Nakamura T, Shirouzu T, kawai S et al. Detection of Intragraft Anti-Blood Group A and B Antibodies Following Renal Transplantation. Transplant Proc. 2019 Jun;51(5):1371-1377.

2. 糖尿病・内分泌疾患関連論文一覧ヘルスケア 2019.07

Maeda T, Miki S, Morihara N et al. Aged garlic extract ameliorates fatty liver and insulin resistance and improves the gut microbiota profile in a mouse model of insulin resistance. Exp Ther Med. 2019 Jul;18(1):857-866.

創薬 2019.07

Stasio DD, Kawasaki H et al. Salivary mir-27b Expression in Oral Lichen Planus Patients: A Series of Cases and a Narrative Review of Literature. Curr Top Med Chem. 2019;19(31):2816-2823.

バイオ 2019.06

Nakamura T, Shirouzu T, Kawai S et al. Detection of Intragraft Anti-Blood Group A and B Antibodies Following Renal Transplantation. Transplant Proc. 2019 Jun;51(5):1371-1377.

バイオ 2019.06

Nakamura T, Shirouzu T, Kawai S et al. Clearance of Intra-graft Donor Specific Anti-HLA Antibodies in the Early Stage of Antibody-Mediated Rejection Following Rituximab and Apheresis Therapy in Renal Transplantation. Transplant Proc. 2019 Jun;51(5):1365-1370.

バイオ 2019.04

Nakamura T, Shirouzu T, Kawai S et al. Graft Immunocomplex Capture Fluorescence Analysis Can Detect Intragraft Anti-Major Histocompatibility Complex Antibodies in Mice Cardiac Transplant. Transplant Proc. 2019 Jun;51(5):1531-1535.

創薬 2019.03

Misso G, Kawasaki H et al. miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma. Mol Ther Nucleic Acids. 2019 Jun 7;16:391-406.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2019.02

Wakamatsu J et al. Antioxidative Maillard Reaction Products Generated in Processed Aged Garlic Extract. J Agric Food Chem. 2019 Feb 27; 67(8):2190-2200.

1. 高血圧・動脈硬化・循環器疾患関連S1PCヘルスケア 2019.02

Matsutomo T, Ushijima M, Kunimura K, Ohtani M. Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. J Pharm Biomed Anal. 2019 May 10;168:148-154.

1. 高血圧・動脈硬化・循環器疾患関連S1PCヘルスケア 2019.01

Tsuneyoshi T, Kunimura K, Morihara N. S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019 Mar 1;84:22-29.

7. 動態・安全性関連ヘルスケア 2018.12

Yamato O, Tsuneyoshi T, Ushijima M, Jikihara H et al. Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes. BMC Vet Res. 2018 Nov 29;14(1):373.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2018.10

Matsutomo T et al. Targeted screening and quantitative analyses of antioxidant compounds in aged-garlic extract. Eur Food Res Technol. 2018 May 19;244(10):1803-1814.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2018.09

Fujii T, Matsutomo T, Kodera Y. Changes of S-allylmercaptocysteine and γ-glutamyl-S-allylmercaptocysteine contents and their putative production mechanisms in garlic extract during the aging process. J Agric Food Chem. 2018 Sep 18;66(40):10506-10512.

6. 免疫機能関連S1PCヘルスケア 2018.09

Suzuki J, Kodera Y, Miki S, Ushijima M, Takashima M, Matsutomo T, Morihara N. Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci Rep. 2018 Sep 20;8(1):14148.

バイオ 2018.06

Nakamura T, Shirouzu T et al. Donor Specific Anti-HLA Antibodies in Organ Transplantation: Transition from Serum DSA to Intra-Graft DSA. Human Leukocyte Antigen (HLA). 2018. IntechOpen

バイオ 2018.06

Grimaldi A, Kawasaki H et al. Non-coding RNAs as a new dawn in tumor diagnosis. Semin Cell Dev Biol. 2018 Jun;78:37-50.

創薬 2018.06

Kawasaki H et al. Determination of miRNAs from Cancer Stem Cells Using a Low Density Array Platform. Methods Mol Biol. 2018;1692:149-156.

創薬 2018.06

Hirano T, Kinoshita T, Kazamori D, Inoue S, Nishimura K, Sakurai A, Ohishi K, Kuramoto Y, Amano H, Yazaki A. Discovery of a Novel Fluoroquinolone Antibiotic Candidate WFQ-228 with Potent Antimicrobial Activity and the Potential to Overcome Major Drug Resistance. Chem Pharm Bull (Tokyo). 2018 Mar 1;66(3):235-238.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2018.05

Nakamoto M, Fujii T, Matsutomo T, Kodera Y. Isolation and Identification of Three γ-Glutamyl Tripeptides and Their Putative Production Mechanism in Aged Garlic Extract. J Agric Food Chem. 2018 Mar 21;66(11):2891-2899.

バイオ 2018.04

Grassia V, Kawasaki H et al. Salivary microRNAs as new molecular markers in cleft lip and palate: a new frontier in molecular medicine. Oncotarget. 2018 Apr 10;9(27):18929-18938.

1. 高血圧・動脈硬化・循環器疾患関連S1PCヘルスケア 2018.04

Ushijima M, Takashima M, Kunimura K, Kodera Y, Morihara N, Tamura K. Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats. J Pharm Pharmacol. 2018 Apr;70(4):559-565.

バイオ 2017.12

Ricciardiello F, Kawasaki H et al. A miRNA signature suggestive of nodal metastases from laryngeal carcinoma. Acta Otorhinolaryngol Ital. 2017 Dec;37(6):467-474.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2017.10

Morihara N, Hino A, Miki S, Takashima M, Suzuki J. Aged garlic extract suppresses inflammation in apolipoprotein E-knockout mice. Mol Nutr Food Res. 2017 Oct;61(10).

バイオ 2017.06

白水隆喜ほか. HLA交差適合性試験試薬ICFA (Ⅰ&Ⅱ) の改良と移植後モニタリング検査. Medical Science Digest. 2017;43:56-59.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2017.05

小川貴裕, 小寺幸広ほか. モデル生物線虫C.elegansを用いた熟成ニンニクの機能解析. 化学と生物. 2017;55(6):372-374.

2. 糖尿病・内分泌疾患関連論文一覧ヘルスケア 2017.05

Miki S, Inokuma K, Takashima M, Nishida M, Sasaki Y, Ushijima M, Suzuki J, Morihara N. Aged garlic extract suppresses the increase of plasma glycated albumin level and enhances the AMP-activated protein kinase in adipose tissue in TSOD mice. Mol Nutr Food Res. 2017 May;61(5):1600797.

8. 熟成ニンニク抽出液の構成成分と分析結果関連S1PCヘルスケア 2017.03

Kodera Y, Ushijima M, Amano H, Suzuki J, Matsutomo T. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract. Molecules. 2017 Mar 31;22(4):570.

1. 高血圧・動脈硬化・循環器疾患関連S1PCヘルスケア 2017.03

Matsutomo T, Ushijima M, Kodera Y, Nakamoto M, Takashima M, Morihara N, Tamura K. Metabolomic study on the antihypertensive effect of S-1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 1;1046:147-155.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2017.02

Morihara N, Hino A. Aged garlic extract suppresses platelet aggregation by changing the functional property of platelets. J Nat Med. 2017 Jan;71:249-256.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2017.02

牛島光保. 熟成ニンニク抽出液の末梢循環改善作用. FOOD Style 21. 2017;21(12):75-77.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2017.01

Takashima M, Kanamori Y, Kodera Y, Morihara N, Tamura K. Aged garlic extract exerts endothelium-dependent vasorelaxant effect on rat aorta by increasing nitric oxide production. Phytomedicine. 2017 Jan 15;24:56-61.

7. 動態・安全性関連S1PCヘルスケア 2016.11

Amano H, Kazamori D, Ioth K. Evaluation of the Effects of S-Allyl-L-cysteine, S-Methyl-L-cysteine, trans-S-1-Propenyl-L-cysteine, and Their N-Acetylated and S-Oxidized Metabolites on Human CYP Activities. Biol Pharm Bull. 2016;39(10):1701-1707.

7. 動態・安全性関連S1PCヘルスケア 2016.11

Amano H, Kazamori D, Ioth K. Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs. Xenobiotica. 2016 Nov;46(11):1017-1025.

6. 免疫機能関連S1PCヘルスケア 2016.08

Suzuki J, Yamaguchi T, Matsutomo T, Amano H, Morihara N, Kodera Y. S-1-Propenylcysteine promotes the differentiation of B cells into IgA-producing cells by the induction of Erk1/2-dependent Xbp1 expression in Peyer’s patches. Nutrition. 2016 Jul-Aug;32(7-8):884-889.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2016.06

Matsutomo T et al. Development of a fast and sensitive UPLC-MS/MS method for quantitation of dilignols in aged garlic extract. Eur Food Res Technol. 2016 Jun;242(6):849-854.

創薬 2016.04

Kitaoka S et al. FGT-1-mediated glucose uptake is defective in insulin/IGF-like signaling mutants in Caenorhabditis elegans. FEBS Open Bio. 2016 Apr 21;6(6):576-585.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2016.02

Matsutomo T, Kodera Y. Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection. J Nutr. 2016 Feb;146(2):450S-455S.

7. 動態・安全性関連ヘルスケア 2016.02

Amano H, Kazamori D, Ioth K. Pharmacokinetics of S-Allyl-l-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption. J Nutr. 2016 Feb;146(2):456S-459S.

9. その他ヘルスケア 2016.02

Ogawa T, Kodera Y et al. Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep. 2016 Feb 22;6:21611.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2016.02

Morihara N, Hino A, Yamaguchi T, Suzuki J. Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice. J Nutr. 2016 Feb;146(2):460S-463S.

1. 高血圧・動脈硬化・循環器疾患関連ヘルスケア 2016.02

Hiramatsu K, Tsuneyoshi T, Ogawa T, Morihara N. Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2-related factor 2-antioxidant response element signaling pathway in human endothelial cells. Nutr Res. 2016 Feb;36(2):143-149.

8. 熟成ニンニク抽出液の構成成分と分析結果関連ヘルスケア 2016.01

Wakamatsu J et al. Taste-Active Maillard Reaction Products in Roasted Garlic (Allium sativum). J Agric Food Chem. 2016 Jul 27;64(29):5845-5854.

S1PC

Kodera Y, Matsutomo T, Itoh K. The Evidence for the Production Mechanism of cis-S-1-Propenylcysteine in Aged Garlic Extract Based on a Model Reaction Approach Using Its Isomers and Deuterated Solvents. Planta Med Lett. 2015;2(01):e69-e72.

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Tsuneyoshi T, Kanamori Y, Matsutomo T, Morihara N. Dehydrodiconiferyl alcohol suppresses monocyte adhesion to endothelial cells by attenuation of JNK signaling pathway. Biochem Biophys Res Commun. 2015 Sep 25;465(3):408-413.

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Weiss N, Morihara N, Ide T et al. Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation. J Ethnopharmacol. 2013 Jan 9;145(1):162-167.

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Higashikawa F, Ushijima M et al. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2012 Apr;31(2):261-266.

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Morihara N, Ide N et al. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. J Ethnopharmacol. 2011 April 12;134(3):711-716.

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Morihara N, Ide N et al. Aged garlic extract inhibits CD36 expression in human macrophages via modulation of the PPARgamma pathway. Phytother Res. 2010 April;24(4):602-608.

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Abahji TN, Ide N et al. Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction. Arch Med Res. 2007 May;38(4):411-416.

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Weiss N, Ide N et al. Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro-and microcirculation. J Nutr. 2006 Mar;136(3 Suppl):750S-754S.

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Ide N et al. Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages. J Nutr. 2006 Mar;136(3 Suppl):755S-758S.

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Harauma A, Moriguchi T. Aged garlic extract improves blood pressure in spontaneously hypertensive rats more safely than raw garlic. J Nutr. 2006 Mar;136(3 Suppl):769S-773S.

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Morihara N, Sumioka I, Ide N, Moriguchi T, Uda N, Kyo E. Aged garlic extract maintains cardiovascular homeostasis in mice and rats. J Nutr. 2006 Mar;136(3 Suppl):777S-781S.

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Sumioka I, Hayama M, Shimokawa Y, Shiraishi S et al. Lipid-lowering effect of monascus garlic fermented extract (MGFE) in hyperlipidemic subjects. Hiroshima J Med Sci. 2006 Jun;55(2):59-64.

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Morihara N, Ide N, Sumioka I, Kyo E. Aged garlic extract inhibits peroxynitrite-induced hemolysis. Redox Rep. 2005;10(3):159-165.

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Budoff MJ, Amagase H et al. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. 2004 Nov;39(5):985-991.

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Morihara N, Sumioka I, Moriguchi T, Uda N, Kyo E. Aged garlic extract enhances production of nitric oxide. Life Sci. 2002 Jun 21;71(5):509-517.

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Ide N, Lau BHS. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J Nutr. 2001 Mar;131(3s):1020S-1026S.

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Ho SE, Ide N et al. S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process. Phytomedicine. 2001 Jan;8(1):39-46.

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Matsuura H. Saponins in garlic as modifiers of the risk of cardiovascular disease. J Nutr. 2001 Mar;131(3s):1000S-1005S.

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Moriguchi T, Takasugi N, Itakura Y. The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes. J Nutr. 2001 Mar;131(3s):1016S-1019S.

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Ide N et al. Aged garlic extract attenuates intracellular oxidative stress. Phytomedicine. 1999 May;6(2):125-131.

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Ide N et al. S-allylcysteine attenuates oxidative stress in endothelial cells. Drug Dev Ind Pharm. 1999 May;25(5):619-624.

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Ide N et al. Aged garlic extract and its constituents inhibit Cu(2+)-induced oxidative modification of low density lipoprotein. Planta Med. 1997 Jun;63(3):263-264.

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Ide N, Lau BH. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. J Pharm Pharmacol. 1997 Sep;49(9):908-911.

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Yamasaki T et al. Garlic compounds protect vascular endothelial cells from oxidant injury. Nihon Yakurigaku Zasshi. 1997 Oct;110(Suppl 1):138-141.

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Yamasaki T et al. Garlic compounds protect vascular endothelial cells from hydrogen peroxide-induced oxidant injury. Phytother Res. 1994;8(7):408-412.

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永井勝次, 松中淳子. ラットの血圧に及ぼすニンニク抽出液の影響. 薬理と治療. 1975;3(2):255-260.

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Adachi Y, Yoshida J, Kodera Y et al. Bis(allixinato)oxovanadium(IV) complex is a potent antidiabetic agent: Studies on structure-activity relationship for a series of hydroxypyrone-vanadium complexes. J Med Chem. 2006 Jun 1;49(11):3251-3256.

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Adachi Y, Yoshida J, Kodera Y et al. Improvement of diabetes, obesity and hypertension in type 2 diabetic KKAy mice by bis(allixinato)oxovanadium(IV) complex. Biochem Biophys Res Commun. 2006 Jul 7;345(3):945-950.

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Adachi Y, Yoshida J, Kodera Y et al. A highly potent insulin-mimetic zinc(II) complex a Zn(S2O2) coordination mode: Bis(1,6-dimethyl-3-hydroxy-5-methoxy-2-pentyl-1,4-dihydropyridine-4-thionato)zinc(II). Chem Lett. 2005 May;34(5):656-657.

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Adachi Y, Yoshida J, Kodera Y et al. A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes. J Biol Inorg Chem. 2004 Oct;9(7):885-893.

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春日繁男, 牛島光保, 森原直明, 板倉洋一ほか. マウスのストレス性高血糖に対するニンニク抽出液（AGE）の作用. 日本薬理学雑誌. 1999;114(3):191-197.

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永井勝次, 中川静紀. 糖尿病におよぼすニンニク，ニンジン抽出液の影響. 薬理と治療. 1974 Oct;2(9):1473-1489.

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Hoshino T, Kashimoto N, Kasauga S. Effects of Garlic Preparations on the Gastrointestinal Mucosa. J Nutr. 2001 Mar;131(3s):1109S-1113S.

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Sumioka I et al. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice. Eur J Pharmacol. 2001 Dec 21;433(2-3):177-185.

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Horie T, Fuwa T et al. Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration. Planta Med. 1999 Aug;65(6):545-548.

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Sumioka I, Kasuga S, Itakura Y et al. Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice. Jpn J Pharmacol. 1998 Oct;78(2):199-207.

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Nakagawa S, Kasuga S, Matsuura H. Prevention of liver damage by aged garlic extract and its components in mice. Phytother Res. 1989;3(2):50-53.

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Nakagawa S, Yoshida S, Hirao Y, Kasuga S, Fuwa T. Cytoprotective activity of components of garlic, ginseng and ciuwjia on hepatocyte injury induced by carbon tetrachloride in vitro. Hiroshima J Med Sci. 1985 Sep;34(3):303-309.

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永井勝次, 大沢せい子, 中川静紀. ニンニク抽出液投与によるマウス肝の電顕的研究 第3報 経過日数と電顕的変化. 薬理と治療. 1975;3(3):423-426.

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永井勝次, 大沢せい子, 中川静紀. ニンニク抽出液投与によるマウス肝の電顕的研究 第2報 投与回数と電顕的変化. 薬理と治療. 1974 Nov;2(10):1636-1638.

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永井勝次. ニンニク抽出液投与による肝の電顕的考察. 診療と保険. 1972;14(12):1477-1478.

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Kohda K, Morihara N, Kodera Y, Oka T et al. Enhancing Effect of Aged Garlic Extract on Induction of Morphological Differentiation with Neurite Outgrowth in NGF-treated PC12 Cells. Pharmacol Pharm. 2012;3(1):37-43.

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武田秀勝, 吉良和也, 隅岡功, 葉山実ほか. 学生の試験ストレスに対する熟成ニンニク抽出液（AGE）の効果. 北方産業衛生. 2011;48:15-20.

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Moriguchi T et al. Aged garlic extract as a neurotrophic and anti-aging agent. Piante Medicinali. 2002;1(3):114-128.

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Nishiyama N, Moriguchi T, Morihata N et al. Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice. J Nutr. 2001 Mar;131(3s):1093S-1095S.

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Sumi S, Tsuneyoshi T, Matsuo H, Yoshimatsu T. Isolation and characterization of the genes up-regulated in isolated neurons by aged garlic extract (AGE). J Nutr. 2001 Mar;131(3s):1096S-1099S.

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住吉博道. ニンニクが脳機能に及ぼす作用. Food Style21. 1999;3:36-40.

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Moriguchi T, Matsuura H, Itakura Y et al. Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity. Life Sci. 1997;61(14):1413-1420.

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Moriguchi T et al. Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model. Clin Exp Pharmacol Physiol. 1997 Mar-Apr;24(3-4):235-242.

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Nishiyama N, Moriguchi T et al. Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse. Exp Gerontol. 1997 Jan-Apr;32(1-2):149-160.

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Moriguchi T, Matsuura H, Kodera Y, Itakura Y et al. Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons. Neurochem Res. 1997 Dec;22(12):1449-1452.

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Moriguchi T et al. Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse. Biol Pharm Bull. 1996 Feb;19(2):305-307.

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Nishiyama N, Moriguchi T et al. Effects of aged garlic extract on senescence accelerated mouse and cultured brain neurons. Int Acad Biomed Drug Res. 1996;11:253-258.

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Moriguchi T et al. Tropic effects of aged garlic extract (AGE) and its fractions on primary cultured hippocampal neurons from fetal rat brain. Phytother Res. 1996;10:468-472.

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西山信好, 守口徹ほか. 老化および老化に伴う記憶障害に対するニンニクの予防効果. 新薬と臨牀. 1996;45(3):467-473.

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Moriguchi T et al. Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract. Biol Pharm Bull. 1994 Dec;17(12):1589-1594.

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Morihara N, Nishihama T, Ushijima M, Ide N, Hayama M et al. Garlic as an anti-fatigue agent. Mol Nutr Food Res. 2007 Nov;51(11):1329-1334.

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Morihara N, Ushijima M, Kashimoto N, Sumioka I, Nishihama T, Hayama M et al. Aged garlic extract ameliorates physical fatigue. Biol Pharm Bull. 2006 May;29(5):962-966.

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木本理可, 許栄海ほか. 熟成ニンニク抽出液が日常定期的運動負荷時および一時的最大運動負荷時の尿中8-OHdG含有量推移に及ぼす影響. 北海道スポーツ医・科学雑誌. 2005;10:17-26.

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春日繁男. ニンニク抽出液が持久性運動負荷による生体に及ぶ影響. 北海道スポーツ医・科学雑誌. 1998;6:29-36.

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Ushijima M, Sumioka I, Kakimoto M, Yokoyama K, Uda N, Matsuura H, Kyo E, Suzuki A, Kasuga S, Itakura Y, Amagase H et al. Effect of garlic and garlic preparations on physiological and psychological stress in mice. Phytother Res. 1997 May;11(3):226-230.

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Takasugi N, Kotoo K, Fuwa T et al. Effect of garlic on mice exposed to various stresses. 応用薬理. 1984;28(6):991-1002.

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Yamakawa T, MatsutomoT, Kodera Y et al. Aged Garlic Extract and One of the Constituent, (+)-(2S,3R)-Dehydrodiconiferyl Alcohol, Inhibits Alkaline Phosphatase Activity Induced by Inflammation Factors in Human Vascular Smooth Muscle Cells. Food Nutr Sci. 2014 Jan;5(2):177-184.

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木本理可, 許栄海ほか. 熟成ニンニク抽出液の摂取が大学生の臨床実習における尿中8-OHdG排泄量，NK細胞活性およびPOMS得点に与える影響. 北海道教育大学紀要. 2005;56(1):47-53.

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Kyo E, Uda N, Kasuga S, Itakura Y. Immunomodulatory effects of aged garlic extract. J Nutr. 2001 Mar;131(3s):1075S-1079S.

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Kasuga S, Uda N, Kyo E, Ushijima M, Morihara N, Itakura Y. Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. J Nutr. 2001 Mar;131(3s):1080S-1084S.

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Kyo E, Uda N, Ushijima M, Kasuga S, Itakura Y. Prevention of psychological stress-induced immune suppression by aged garlic extract. Phytomedicine. 1999 Nov;6(5):325-330.

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Zhang Y, Moriguchi T et al. Functional relationship between age-related immunodeficiency and learning deterioration. Eur J Neurosci. 1998 Dec;10(12):3869-3875.

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Kyo E, Uda N, Kakimoto M, Yokoyama K, Ushijima M, Sumioka I, Kasuga S, Itakura Y. Anti-allergic effects of aged garlic extract. Phytomedicine. 1997 Dec;4(4):335-340.

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Lau BH, Yamasaki T et al. Garlic compounds modulate macrophage and T-lymphocyte functions. Mol Biother. 1991 Jun;3(2):103-107.

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Hirao Y, Sumioka I, Nakagami S, Yamamoto M, Hatono S, Yoshida S, Fuwa T, Nakagawa S. Activation of immunoresponder cells by the protein fraction from aged garlic extract. Phytother Res. 1987 Dec;1(4):161-164.

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永井勝次. ウイルスの感染防御に及ぼすニンニク抽出液の影響. 日本感染症学会雑誌. 1973;47(4):111-115.

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永井勝次. ニンニク抽出液のインフルエンザ感染防御に及ぼす影響. 日本感染症学会雑誌. 1973;47(9):321-325.

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Amano H, Kazamori D, Ioth K, Kodera Y. Metabolism, excretion, and pharmacokinetics of S-allyl-L-cysteine in rats and dogs. Drug Metab Dispos. 2015 May;43(5):749-755.

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Matsutomo T, Ichikawa M, Kodera Y. Pharmacokinetics of water soluble organosulfur compounds from garlic. J Clin Biochem Nutr. 2008 July;43(supple 1):100-104.

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Ichikawa M, Mizuno I, Yoshida J, Ide N, Ushijima M, Kodera Y, Hayama M et al. Pharmacokinetics of cycloalliin, an organosulfur compound found in garlic and onion, in rats. J Agric Food Chem. 2006 Dec 27;54(26):9811-9819.

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Henry M, Amagase H et al. Aged garlic extract may be safe for patients on warfarin therapy. J Nutr. 2006 Mar;136(3 Suppl):793S-795S.

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Kodera Y, Ichikawa M, Yoshida J, Kashimoto N, Uda N, Sumioka I, Ide N et al. Pharmacokinetic study of allixin, a phytoalexin produced by garlic. Chem Pharm Bull (Tokyo). 2002 Mar;50(3):354-363.

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Nagae S, Ushijima M, Hatono S, Imai J, Kasuga S, Matsuura H, Itakura Y et al. Pharmacokinetics of the garlic compound S-allylcysteine. Planta Med. 1994 Jun;60(3):214-217.

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吉田進, 平尾勇造, 中川静紀. ニンニクの変異原性試験および細胞毒性試験. J Toxicol Sci. 1984;9(1):77-86

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中川静紀, 政本浩二, 住吉博道, 原田浩. ニンニク抽出液の急性毒性試験. J Toxicol Sci. 1984;9(1):57-60.

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住吉博道, 兼澤敦, 政本浩二, 原田浩, 中上智, 横田敦子, 西川翠, 中川静紀. ニンニク抽出液のラットにおける6ヶ月慢性毒性試験. J Toxicol Sci. 1984;9(1):61-75.

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中川静紀, 政本浩二, 住吉博道, 国弘和雄, 不破亨. 生ニンニクおよびニンニク抽出液の経口投与による若年ラットの発育，諸臓器などへの影響. J Toxicol Sci. 1980;5(1):91-112.

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Yoshimoto N, Sumi S, Tsuneyoshi T et al. Garlic γ-glutamyl transpeptidases that catalyze deglutamylation of biosynthetic intermediate of alliin. Front Plant Sci. 2015 Jan 8;5:758.

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Kodera Y, Matsutomo T, Itoh K. The Evidence for the Production Mechanism of cis-S-1-Propenylcysteine in Aged Garlic Extract Based on a Model Reaction Approach Using Its Isomers and Deuterated Solvents. Planta Med Lett. 2015;2(01):e69-e72.

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Yoshimoto N, Tsuneyoshi T, Sumi S et al. Identification of a flavin-containing S-oxygenating monooxygenase involved in alliin biosynthesis in garlic. Plant J. 2015 Sep;83(6):941-951.

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Matsutomo T et al. In vitro activity-guided identification of antioxidants in aged garlic extract. J Agric Food Chem. 2013 Mar 27;61(12):3059-3067.

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Ichikawa M, Ide N et al. Changes in organosulfur compounds in garlic cloves during storage. J Agric Food Chem. 2006 Jun 28;54(13):4849-4854.

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Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006 Mar;136(3 Suppl):716S-725S.

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Ichikawa M, Ide N, Yoshida J, Yamaguchi H et al. Determination of seven organosulfur compounds in garlic by high-performance liquid chromatography. J Agric Food Chem. 2006 Mar 8;54(5):1535-1540.

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Ichikawa M, Yoshida J, Ide N, Sasaoka T, Yamaguchi H et al. Tetrahydro-beta-carboline derivatives in aged garlic extract show antioxidant properties. J Nutr. 2006 Mar;136(3 Suppl):726S-731S.

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Ichikawa M, Ryu K, Yoshida J, Ide N, Yoshida S, Sasaoka T, Sumi S. Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract. ACS SYMPOSIUM SERIES, Vol 871, Nutraceutical Beverages Chemistry, Nutrition, and Health Effects. 2003 Dec 1;Chapter 28:380-404.

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Ide N, Ichikawa M, Ryu K, Yoshida J, Sasaoka T, Sumi S, Sumiyoshi H. Antioxidants in Processed Garlic: Tetrahydro-β-carboline derivatives in aged garlic extract. ACS SYMPOSIUM SERIES, Vol 851, Food Factors in Health Promotion and Disease Prevention. 2003 Jun 19;Chapter 22:250-263.

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Kodera Y, Matsuura H, Sumiyoshi H, Sumi S. Garlic chemistry: Chemical and biological properties of sulfur-containing compounds derived from garlic. ACS Symposium series, Vol 851, Food Factors in Health Promotion and Disease Prevention. 2003 Jun 19;Chapter 30:346-357.

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Ichikawa M, Ryu K, Yoshida J, Ide N, Kodera Y, Sasaoka T et al. Identification of six phenylpropanoids from garlic skin as major antioxidants. J Agric Food Chem. 2003 Dec 3;51(25):7313-7317.

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Ryu K, Ide N, Ichikawa M, Ogasawara K et al. Liquid Chromatography-Mass Spectrometry Method for Fructosylarginine, an Antioxidant in the Aged Garlic Extract. ACS SYMPOSIUM SERIES, Vol 851, Food Factors in Health Promotion and Disease Prevention, 2003 Jun 19;Chapter 23:264-273.

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Ryu K, Rosen RT. Unique Chemistry of Aged Garlic Extract. ACS SYMPOSIUM SERIES, Vol 859, Oriental Foods and Herbs. 2003 Aug 5;Chapter 19:258-270.

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Kodera Y, Ayabe M, Ogasawara K, Yoshida S, Hayashi N et al. Allixin accumulation with long-term storage of garlic. Chem Pharm Bull (Tokyo). 2002 Mar; 50(3):405-407.

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Ichikawa M, Ryu K, Yoshida J, Ide N, Yoshida S, Sasaoka T, Sumi S. Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract. Biofactors. 2002;16(3-4):57-72.

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Ide N, Ichikawa M, Ryu K, Ogasawara K, Yoshida J, Yoshida S, Sasaoka T, Sumi S, Sumiyoshi H. Antioxidants in processed garlic Ⅱ. Tetrahydro-beta-carboline derivatives identified in aged garlic extract. Int Cong Ser. 2002 Nov;1245:449-450.

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Ide N, Ryu K, Ogasawara K, Sasaoka T, Matsuura H, Sumi S, Sumiyoshi H et al. Antioxidants in processed garlic I. Fructosyl arginine identified in aged garlic extract. Int Cong Ser. 2002 Nov;1245:447-448.

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Kodera Y, Suzuki A, Imada O, Kasuga S, Sumioka I, Kanezawa A, Taru N, Fujikawa M, Nagae S, Masamoto K, Maeshige K et al. Physical, chemical, and biological properties of s-allylcysteine, an amino acid derived from garlic. J Agric Food Chem. 2002 Jan 30;50(3):622-632.

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Ryu K, Ide N, Matsuura H, Itakura Y. N alpha-(1-deoxy-D-fructos-1-yl)-L-arginine, an antioxidant compound identified in aged garlic extract. J Nutr. 2001 Mar;131(3s):972S-976S.

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Kodera Y, Ayabe M, Ogasawara K et al. Allixin induction and accumulation by light irradiation. Chem Pharm Bull (Tokyo). 2001 Dec;49(12):1636-1637.

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Ide N, Ryu K, Matsuura H, Itakura Y et al. Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract. J Nutr. Biochem. 1999 Jun;10(6):372-376.

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Inagaki M, Matsuura H, Itakura Y et al. Isolatin and structure determination of cerebrosides from garlic, the bulbs of Allium sativum L. Chem Pharm Bull (Tokyo). 1998 Jul;46(7):1153-1156.

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Ide N, Matsuura H, Itakura Y. Scavenging effect of aged garlic extract and its constutuent on active oxygen species. Phytother Res. 1996;10:340-341.

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五十嵐厚美, 中野浩美, 山根明男ほか. PCR法による臨床検査材料からの肺炎球菌の短時間検出について. 日本化学療法学会雑誌. 1995;43(11):1031-1035.

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Fumihito A, Miyake T, Sumi S et al. One subspecies of the red junglefowl (Gallus gallus spadiceus) suffices as the matriarchic ancestor of all domestic brees. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12505-12509.

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Arai M, Kawai S et al. DNA diagnosis of Ovale malaria and Malariae malaria using microtitter plate-hybridization. Nucleosides Nucleotides. 1994;13(6&7):1363-1374.

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Oka T et al. Human monoclonal antibody identified an immunoreactive tetrapeptide sequence (Lys-Tyr-Gln-Ile) in M(r) 43,000 protein of human melanoma. Cancer Res. 1994 Jul 1;54(13):3511-3515.

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Kawai S, Maekawajiri S, Yamane A et al. A simple method of HLA-DRB typing using enzymatically amplified DNA and immobilized probes on microtiter plate. Hum Immunol. 1994 Oct;41(2):121-126.

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Oka T, Matsunaga H, Yamane A et al. A simple method for detecting single base substitutions and its application to HLA-DPB1 typing. Nucleic Acids Res. 1994 May 11;22(9):1541-1547.

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Yoshimatsu T, Nagawa F. Effect of artificially inserted intron on gene expression in Saccharomyces cerevisiae. DNA Cell Biol. 1994 Jan;13(1):51-58.

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呉銀, 山根昭男ほか. ED-PCR(Enzymatic detection of polymerase chain reaction)を用いたVibrio vulnificusヘモリジン遺伝子の検出. 日本細菌学雑誌. 1994;49(2):409-410.　

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生方公子, 山根明男ほか. ペニシリン耐性肺炎球菌の臨床分離株における薬剤耐性機構について ペニシリン結合蛋白とPBP2B遺伝子の解析. 日本化学療法学会雑誌. 1994;42(11):1225-1235.

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吉松忠憲, 名川文清. 酵母による遺伝子発現のためのイントロンのデザイン. 日本農芸化学会誌. 1993;67(5):853-856.

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Kawai S, Maekawajiri S, Yamane A. A simple method of detecting amplified DNA with immobilized probes on microtiter wells. Anal Biochem. 1993 Feb 15;209(1):63-69.

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Yokozaki H, Kyo E et al. A monoclonal antibody capable of detecting new differentiation antigen of the stomach. Int J Cancer. 1992 Feb 20;50(4):523-527.

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Ubukata K, Nakagami S, Nitta A, Yamane A et al. Rapid detection of the mecA gene in methicillin-resistant Staphylococci by enzyme detection polymerase chain reaction products. J Clin Microbiol. 1992 Jul;30(7):1728-1733.

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名川文清, 吉松忠憲. イントロンカセットによる遺伝子発現抑制. 酵母研究技法の新展開. 1991:p15-21. 学会出版センター.

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脇坂真司, 中上智. 非放射性標識による遺伝子検出. 醗酵工学会誌. 1991;69(6):528.

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Nakagami S, Matsunaga H, Oka N, Yamane A. Preparation of enzyme-conjugated DNA probe and application to the universal probe system. Anal Biochem. 1991 Oct;198(1):75-79.

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Ito T, Ohshita Y et al. Identification and nucleotide sequence determination of the gene responsible for Ogawa serotype specificity of V. choletae 01. FEBS Lett. 1991 Jul 29;286(1-2):159-162.

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Misoka F, Sakamoto S, Miyake T et al. High level expression of human transforming growth factor alfa gene in Escherichia coli in a fusion gene system with human growth hormone gene. J Ferment Bioengineeing. 1991;71(4):216-220.

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Nakagami S, Matsunaga H, Miyoshi K, Yamane A. Nonradioactive detection of nucleic acid by the universal probe system. Anal Biochem. 1991 Jan;192(1):11-16.

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Yanai S, Fuwa T et al. Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver. Pharm Res. 1991 May;8(5):557-562.

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Suzuki H et al. Gene mapping of mouse IL-4 receptor: the loci of interleukin 4 (IL-4) receptor gene and lymphocyte function associated antigen 1 (LFA-1) gene are closely linked on chromosome 7. Immunogenetics. 1991;34(4):252-256.

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Wakisaka S et al. Properties of Brevibacterium flavum glutamine synthetase in an "in vivo-like" system. J Ferment Bioeng. 1990;70(3):182-184.

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Kajimura Y et al. Application of long synthetic oligonucleotide for gene analysis: Effect of probe length and stringency conditions on hybridization specificity. Genet Anal Tech Appl. 1990 Jun;7(4):71-79.

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Sagara Y, Miyoshi K et al. Structual organization of the bovine adrenodoxin gene. J Biochem. 1990 Jan;107(1):77-83.

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Misoka F, Miyake T, Miyoshi K, Sakamoto S, Fuwa T et al. Overproduction of huma insulin-like growth factor-II in Escherichia coli. Biotechnol Lett. 1989 Dec;11(12):839-844.

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山根明男. 蛍光標識オリゴヌクレオチドのDNA検出法への応用. バイオサイエンスとバイオインダストリー. 1989;47:1063-1067.

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白尾国昭, 松岡秀一, 許栄海ほか. 9A3抗原－定量化および胃癌とくにBorrmann 4型胃癌診断への応用－. Oncologia. 1989;22(2):74-81.

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Yoshimatsu T, Nagawa F. Control of gene expression by artificial introns in Saccharomyces cerevisiae. Science. 1989 Jun 16;244(4910):1346-1348.

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Wakisaka S et al. Glutamate formation by a new in vitro enzym system consisting of purified glutamine synthetase and glutamate synthase. J Ferment Bioeng. 1989;67(6):395-398.

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永井宣隆, 穂積豊治ほか. ビオチン標識RNAプローブを用いたIn situハイブリダイゼーションによるHPV16型,18型初期遺伝子E6/E7mRNAの子宮頚部前癌病変における局在の検討. 日本産科婦人科学会雜誌. 1988;40(9):1455-1456.

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Koide H, Oka T, Kawai S, Miyake T, Fuwa T et al. Biosynthesis of a protein containing a nonprotein amino acid by Escherichia coli: L-2-aminohexanoic acid at position 21 in human epidermal growth factor. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6237-6241.

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Suzuki H, Okubo Y, Moriyama M, Sasaki M, Matsumoto Y, Hozumi T. Human monoclonal antibodies to Pseudomonas aeruginosa produced by EBV-transformed cells. Microbiol Immunol. 1987;31(10):959-966.

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Wakisaka S et al. A rapid assay method for ammonia using glutamine synthetase from glutamate-producing bacteria. Anal Biochem. 1987 May 15;163(1):117-122.

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三宅哲雄. ヒト上皮細胞成長因子の遺伝子合成と大腸菌による分泌生産. BIOmedica. 1987;2(1):22-26.

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Oka T, Sumi S, Fuwa T, Miyake T et al. Efficacies of different secretion vectors for secretion of human epidermal growth factor by Escherichia coli. Agric Biol Chem. 1987;51(4):1099-1104.

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Nagawa F, Fink GR. The relationship between the "TATA" sequence and transcription initiation sites at the HIS4 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1985 Dec 15;82(24):8557-8561.

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Sumi S, Hasegawa A, Yagi S, Miyoshi K, Kanezawa A, Nakagawa S, Suzuki M. Overproduction of human epidermal growth factor/urogastrone in Escherichia coli and demonstration of its full biological activities. J Biotechnol. 1985 Mar;2(2):59-74.

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Oka T, Sakamoto S, Miyoshi K, Fuwa T, Miyake T et al. Synthesis and secretion of human epidermal growth factor by Escherichia coli. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7212-7216.

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Miyake T, Oka T, Nishizawa T, Misoka F, Fuwa T et al. Secretion of human interferon-alpha induced by using secretion vectors containing a promoter and signal sequence of alkaline phosphatase gene of Escherichia coli. J Biochem. 1985 May;97(5):1429-1436.

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廣瀬忠明, 鈴木正則. 遺伝子操作技術の基本. ファルマシアレビュー. 1984;15:27-34.

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Otsuka E, Yamane A et al. Chemical synthesis of the 5'-half molecule of E. coli tRNA2GLY. Tetrahedron. 1984;40(1):47-57.

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角愼一郎, 鈴木正則. セクレチンの合成. 化学の領域. 1983;37(6):403-412.

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鈴木正則. 遺伝子工学の医薬品への応用と問題点. 病院薬学. 1983;9(3):215-231.

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Tachiki T, Wakisaka S et al. Variation of properties of Micrococcus glutamicus glutamine synthetase brought about by divalent cations. Agric Biol Chem. 1983;47(2):287-292.

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Kajimura Y et al. Cloning the heavy chain of human HLA-DR antigen using synthetic oligodeoxyribonucleotides as hybridization probes. DNA Cell Biol. 1983;2(3):175-182.

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Tachiki T, Wakisaka S et al. Glutamine production in high concentrations with energy transfer employing glutamine synthetase from Micrococcus glutamicus. J Gen Appl Microbiol. 1983;29(5):355-363.

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Tachiki T, Wakisaka S et al. Purification and some properties of glutamate synthase from Gluconobacter suboxydans growth on glutamate as a nitrogen source. J Ferment Technol. 1983;61(2):179-184.

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鈴木正則. 遺伝子工学によるセクレチンの開発について－その技術的概要と開発の経過－. 生命工学. 1982;1(2):12-23.

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豊田裕夫, 梶村芳雄ほか. HLA遺伝子とそのクローニング－特にDR領域について－. 代謝. 1982;19(臨時増刊):1705-1716.

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三好健一, 鈴木正則. 固相法によるオリゴヌクレオチドの合成と遺伝子工学への利用. 生物物理. 1982;22(6):246-255.

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鈴木正則. 遺伝子工学による医薬品：研究・臨床の現状 セクレチン. 日本臨牀. 1982;40(8):1791-1796.

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Suzuki M, Sumi S, Hasegawa A, Nishizawa T, Miyoshi K, Wakisaka S, Miyake T, Misoka F. Production in Escherichia coli of biologically active secretin, a gastrointestinal hormone. Proc Natl Acad Sci U S A. 1982 Apr 15;79(8):2475-2479.

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Komai N, Nishizawa T et al. Detection and mapping of six miniF-encoded proteins by cloning analysis of dissected miniF segments. Mol Gen Genet. 1982;186(2):193-203.

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Wallace RB, Miyake T et al. The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA. Nucleic Acids Res. 1981 Feb 25;9(4):879-894.

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Miyoshi K, Hasegawa A, Miyake T et al. Chemical synthesis of 27-desamidosecretin gene by the polymer support method. Nucleic Acids Symp Ser. 1981;(10):197-200.

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Wallace RB, Miyoshi K et al. A set of synthetic oligodeoxyribonucleotide primers for DNA sequencing in the plasmid vector pBR322. Gene. 1981 Dec;16(1-3):21-26.

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Dembek P, Miyoshi K et al. Solid-phase synthesis of hentriacontanucleotide. J Am Chem Soc. 1981 Feb 1;103(3):706-708.

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Tachiki T, Wakisaka S et al. Glutamine synthetase from Micrococcus glutamicus: Effects of nitrogen sources in culture medium on enzyme formation and some properties of crystalline enzyme. Argic Biol Chem. 1981 Jun 1;45(6):1487-1492.

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Tachiki T, Wakisaka S et al. Crystallization of glutamine synthetase from Micrococcus glutamicus. Agric Biol Chem. 1981;45(2):549-550.

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Miyoshi K, Itakura K. Solid-phase synthesis of polynucleotides. V. Synthesis of oligodeoxyribonucleotides by the phosphomonotriazolide methods. Nucleic Acids Symp Ser. 1980;(7):281-291.

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Miyoshi K et al. Solid-phase synthesis of polynucleotides. IV. Usage of polystyrene resins for the synthesis of polydeoxyribonucleotides by the phosphotriester method. Nucleic Acids Res. 1980 Nov 25;8(22):5507-5517.

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Miyoshi K et al. Solid-phase synthesis of polynucleotides. III. Synthesis of polynucleotides with defined sequences by the block coupling phosphotriester method. Nucleic Acids Res. 1980 Nov 25;8(22):5491-5505.

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Miyoshi K, Miyake T, Hozumi T et al. Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method. Nucleic Acids Res. 1980 Nov 25;8(22):5473-5489.

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Tabushi I, Yazaki A et al. Artificial photosynthesis system of bacteria type. Tetrahedron Lett. 1980;21(4):373-376.

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Miyoshi K, Itakura K. Solid-phase synthesis of nonadecathymidylic acid by the phosphotriester approach. Tetrahedron Lett. 1979;20(38):3635-3638.

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Imoto T, Sumi S et al. An analysis of the interaction of sodium dodecyl sulfate with lysozyme. Argic Biol Chem. 1979;43(9):1809-1815.